Figure 3

Histology indicates local neurodegeneration. Hematoxylin and eosin (H&E) images of tissue section showing implant site and surrounding cells. (A) The site of electrode tip is circled. Many pyramidal neuronal cell bodies can be seen (blue arrows). Astrocytes are indicated by yellow arrows; (B) Quantitative analysis revealed a 51% reduction in the number of neurons within a 100-µm radius around the electrode tip compared with control. *p < 0.05. Error bars represent S.E.M.